格列吡嗪

[CAS號] 29094-61-9
[分子式] C21H27N5O4S
[分子量] 445.53
[密度] 1.34 g / cm3
[熔點] 208-209°C
[外觀]白色或類白色結晶性粉末
關於格列吡嗪
Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class.格列吡嗪是磺酰脲類的口服中至長效抗糖尿病藥物。 It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation.它被歸為第二代磺酰脲類，這意味著它經歷了腸肝循環。 The structure on the R2 group is a much larger cyclo or aromatic group compared to the 1st generation sulfonylureas.與第一代磺酰脲相比，R100基團的結構具有更大的環或芳族基團。 This leads to a once a day dosing that is much less than the first generation, about XNUMX fold.這導致每天一次的劑量比第一代要少得多，約為XNUMX倍。