甲苯磺丁酰胺

[CAS號] 64-77-7
[分子式] C12H18N2O3S
[分子量] 270.35
[外觀]白色結晶性粉末
[熔點]128-130ºC
[相對密度] 1.184 g / cm3
關於甲苯磺丁酰胺
Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase.甲苯磺丁胺是第一代鉀通道阻滯劑，磺脲類口服降血糖藥，商品名為Orinase。 This drug may be used in the management of type II diabetes if diet alone is not effective.如果僅飲食無效，則該藥物可用於II型糖尿病的治療。 Tolbutamide stimulates the secretion of insulin by the pancreas.甲苯磺丁酰胺可刺激胰腺分泌胰島素。 Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of type I diabetes.由於胰腺必須合成胰島素才能使這種藥物起作用，因此它在I型糖尿病的治療中無效。 It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as glyburide.與較新的第二代磺酰脲類藥物（如格列本脲）相比，由於不良反應的發生率更高，因此通常不使用這種藥物。