貓薄荷對抗腎癌

Englerin A是最近在非洲植物中發現的天然產物，對腎癌細胞具有高毒性，而對其他細胞則具有低毒性。 This compound is potentially qualified for further evaluation toward an application in cancer therapy.該化合物可能有資格進一步評估其在癌症治療中的應用。 Mathias Christmann, a professor of organic chemistry at TU Dortmund, have noticed that one ingredient of catmint has a structure similar to that of englerin A. Afterwards, he and his colleagues Dr. Matthieu Willot and graduate student Lea Radtke started a program to convert nepetalactone, the active substance of catmint, or Nepeta cataria, into englerin A. As a result, the molecular structure of the starting material - nepetalactone, is altered in the laboratory step-by-step, finally culminating in the target molecule (englerin A).多特蒙德大學有機化學教授馬蒂亞斯·克里斯特曼（Mathias Christmann）注意到，貓薄荷的一種成分具有與英格陵蘭A相似的結構。此後，他和他的同事Matthieu Willot博士以及研究生Lea Radtke啟動了一個轉化荊芥內酯的計劃，即貓薄荷或荊芥的活性物質，轉化為英格列寧A。結果，原料-荊芥內酯的分子結構在實驗室中逐步改變，最終達到目標分子（英格列寧A） 。 The first successful total synthesis, meaning the synthetic production of englerin A on the basis of catmint oil, was completed in summer 2009.首次成功的全合成，即在貓薄荷油的基礎上合成恩格爾林A的生產，已於XNUMX年夏季完成。