HA在皮膚中的生理功能

1.保水
Hyaluronic Acid guarantees the water function in the skin organization is one of its most important physiological functions, Its theory guarantees water number Above 500ml/g, contracts in the organization in the knot the reality to guarantee the water number approximately.HA when high density, its long molecular chain interweaves mutually the lattice, adds it with the water hydrogen bond union, thus plays very strongly guarantees the water role.HA outside the butcher in the matrix main function is The maintenance moisture content, with other sulphating mucopolysaccharide and the collogen, the elastic egg waits in vain the fibrous protein, composes together including outside the massive moisture content butcher the porodine matrix, becomes the cell metabolism the material interchange medium.This kind of watery porodine matrix, causes the skin to be pliable but hard to break, the rich elasticity, the sufficient moisture content causes the flesh smoothly delicate.When skin moist feeling v透明質酸保證皮膚組織中的水分功能是其最重要的生理功能之一,其理論上保證水分含量在XNUMXml / g以上,在組織中收縮的事實保證了水分含量。它的長分子鏈將晶格相互交織,並與水的氫鍵結合,從而起到非常有力的保證水的作用。彈性卵白蛋白纖維蛋白,包括大量的水分在內屠宰的豬rod素基質組成,成為細胞新陳代謝的物質交換介質。這種水po素的基質,使皮膚柔軟但不易斷裂,豐富的彈性,充足的水分使肌膚光滑細膩。 anishing, appears the wrinkle, some people thought is which causes as a result of the HA reduction.Along with the age growth, in the skin the HA content reduces, the skin organization cell and the intercellular space moisture content reduces, the space which by HA the intercellular space which primarily composes the porodine matrix fills to reduce, causes the cell arrangement to be close, the collogen dehydration hardens, causes the skin to be rough, loses the elasticity.Therefore the moisture content regarding the skin health is very important.隨著年齡的增長,皮膚中的HA含量降低,皮膚組織細胞和細胞間空間的水分含量降低,從而導致HA減少。 HA主要組成極化蛋白基質的細胞間隙減少,使細胞排列緊密,膠原蛋白脫水變硬,使皮膚粗糙,失去彈性。因此水分對於皮膚健康非常重要。 Guarantees Shui Baoshi always is the skin care puts on make-up skin care cosmetics) one of most main research topics, also is one of skin appliances main functions.保證水硬性始終是皮膚護理化妝化妝品的最主要研究課題之一,也是皮膚用具的主要功能之一。
2.維護細胞外空間
HA和硫酸軟骨素,硫酸皮膚元素等基質成分並含有大量水分,共同形成肉外層空間,有利於營養供應和新陳代謝廢物的排放,表皮細胞的遷移,免疫細胞(朗格很少有Si細胞與真皮中的淋巴薄層相差。
3.大離子優點
在HA成員鏈上,每個雙醣單元均帶有一個負電荷(一個C00ˉ),使其具有類似的離子交換藥物製備功能,在調節池周圍具有正離子流動和密度。
4.參與角化細胞的變化過程
HA在表皮層緊密參與角質形成細胞的增殖,向外層遷移和分化等,調節整個變化過程,但其自身的代謝激素,生長因子和細胞激活劑(細胞分裂素)等信號員調節。關於黃原酸(視黃酸) )和表皮因表皮生長因子(EGF)生長而刺激HA的生物合成,增加皮膚中HA含量,但氫化則可能使松樹的功能相反。因此,從美容和保護皮膚的角度出發,皮膚表面盡量少使用腎上腺皮質激素類藥物。
5.受體聯合會影響
A與表皮細胞表面的CD44受體結合,促進表皮細胞的正常分化。CD44受體是表皮正常生長和分裂的標誌,當皮膚患有鱗狀細胞癌時,角質細胞分裂停止,隨CD44脫落受體從細胞表面還原與HA有關。HA是細胞存活的信號物質,它與角蛋白細胞表面受體結合,具有一種刺激作用,能減緩對角質的分化,最終消亡。
6.自由基對人體的影響
透明質酸在表皮中的活性氧肥皂,在陽光下紫外線的照射下,由該鹼產生,保護皮膚免除其邪惡,被稱為高效自由基的清道夫。氧自由基可引起脂肪過氧化, HA和氧自由基有反應,自由基被清除,HA被降解。因此HA還具有防止日曬的功能。