芒果苷
[產品名稱] 芒果,芒果
[關於芒果苷]
Mangiferin, a natural polyphenol is known to exhibit anti-inflammatory, antioxidant, and antiviral effects.眾所周知,天然多酚芒果苷具有抗炎,抗氧化和抗病毒作用。 However the molecular mechanism underlying these effects has not been well characterized.但是,尚未很好地表徵這些作用的分子機制。 Because NF- B plays an important role in these processes, it is possible that mangiferin modulates NF- B activation.因為NF-B在這些過程中起著重要作用,所以芒果苷可能會調節NF-B的活化。 Our results show that mangiferin blocks tumor necrosis factor (TNF)-induced NF- B activation and NF- B-dependent genes like ICAM1 and COX2.我們的結果表明,芒果苷可阻斷腫瘤壞死因子(TNF)誘導的NF-B激活和NF-B依賴性基因(如ICAM65和COX2)。 The effect was mediated through inhibition of IKK activation and subsequent blocking of phosphorylation and degradation of IB .In addition, mangiferin inhibits TNF-induced pXNUMX phosphorylation as well as translocation to the nucleus and also inhibits NF- B activation induced by other inflammatory agents like PMA, ceramide, and SA-LPS.該作用是通過抑制IKK激活,隨後阻斷IB的磷酸化和降解來介導的。此外,芒果苷還抑制TNF誘導的pXNUMX磷酸化以及向核的轉運,還抑制了其他炎症劑(如PMA)誘導的NF-B激活。 ,神經酰胺和SA-LPS。 Mangiferin, similar to the other known antioxidants, NAC and PDTC, inhibits TNF-induced reactive oxygen intermediate (ROI) generation.芒果苷與其他已知的抗氧化劑NAC和PDTC相似,可抑制TNF誘導的活性氧中間體(ROI)的生成。 Since intracellular glutathione (GSH) levels are known to modulate NF- B levels, we measured the levels of GSH.由於已知細胞內穀胱甘肽(GSH)水平可調節NF-B水平,因此我們測量了GSH水平。 Mangiferin enhances glutathione level by almost XNUMX-fold more than other anti-oxidants, and at the same time it decreases the levels of GSSG and increases the activity of catalase.芒果苷比其他抗氧化劑將穀胱甘肽水平提高了近XNUMX倍,同時降低了GSSG的水平並增加了過氧化氫酶的活性。 Depletion of GSH by buthionine sulfoximine led to a significant reversal of mangiferin effect.丁硫氨酸亞砜肟對GSH的消耗導致芒果苷作用的顯著逆轉。 Hence mangiferin with its ability to inhibit NF- B and increase the intracellular GSH levels may prove to be a potent drug for anti-inflammatory and antioxidant therapy.因此,芒果苷具有抑制NF-B和增加細胞內GSH水平的能力,可能被證明是抗炎和抗氧化治療的有效藥物。 Mangiferin-mediated down-regulation of NF- B also potentiates chemotherapeutic agent-mediated cell death, suggesting a role in combination therapy for cancer.芒果苷介導的NF-B的下調也增強了化學治療劑介導的細胞死亡,表明在癌症聯合治療中發揮了作用。
[香草來源] 芒果(Cangifra indica L)的葉子Canscora decussata
[分子式和重量] C19H18O11,,422.33
[藥理作用] 抗氧化,抗糖尿病,降血脂,抗腫瘤,抗菌,提高免疫力,抗病毒
[ 物理特性 ] 微黃色結晶粉末,易溶於水,甲醇,乙醇,脂質
[規格] 活性成分:芒果苷,HPLC 60%-90%
[外觀] 從淺黃色到黃綠色粉末
[功能]
Mangiferin from the leaves has been reported to possess antiinflammatory, diuretic, chloretic and cardiotonic activities and displays a high antibacterial activity against gram positive bacteria.據報導,葉子中的芒果苷具有抗炎,利尿,氯和強心活性,並且對革蘭氏陽性細菌顯示出很高的抗菌活性。 It has been recommended as a drug in preventing dental plaques.已推薦將其作為預防牙菌斑的藥物。 Mangiferin shows antiviral effect against type I herpes simplex virus which could be useful in anti-herpes ointments (Unani Herbalist)芒果苷顯示出對I型單純皰疹病毒的抗病毒作用,可用於抗皰疹藥膏(Unani Herbalist)
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