辛伐他汀

[CAS號] 79902-63-9
[ Synonyms ] (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
[分子式] C25H38O5 
[分子量] 418.57 
[外觀]白色結晶粉末
[密度] 1.11 g / cm3
[熔點]139ºC
[沸點]564.9ºC，760 mmHg
[閃點]184.8ºC
[測定] 98％min（HPLC）
[功能與應用] 
（1）辛伐他汀的主要用途是治療血脂異常和預防心血管疾病。
（2）也可用于冠心病患者。
關於辛伐他汀
控制血液中的膽固醇水平並預防心血管疾病。
Simvastatin is a hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia.辛伐他汀是一種降血脂藥物，可與運動，飲食和減肥一起使用，以控制膽固醇升高或高膽固醇血症。 It is a member of the statin class of pharmaceuticals.它是他汀類藥物的成員。
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties.辛伐他汀是具有抗增殖特性的HMGCR（HMG-CoA還原酶）抑製劑。 This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity.已顯示該化合物通過輕微刺激胰凝乳蛋白酶樣活性和抑制肽基谷氨酰胺肽水解活性來調節純化的牛垂體4 S蛋白酶體。 Mechanistic studies suggest that Simvastatin decreases CDK2 and CDK21 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p50 signaling in mesangial cells.機理研究表明，辛伐他汀可降低系膜細胞中CDK13和CDKXNUMX激酶的活性，並抑制高葡萄糖誘導的Rho A（Rho GTPase）/ pXNUMX信號傳導。 Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (ICXNUMX ~ XNUMX µM).辛伐他汀還可以通過抑制TNF誘導的NF-κB活化（ICXNUMX〜XNUMX µM）來增強人類髓樣白血病細胞的凋亡。